Endocrine Abstracts

We report a late presentation of complete androgen insensitivity syndrome (AIS) in a phenotypic female. The patient presented with primary amenorrhoea at age 37, after ten years of heterosexual marriage. She experienced monthly pelvic pain and breast tenderness but no menstrual bleeding. Her family history was significant for primary amenorrhoea in two of her three sisters. Physical examination revealed Tanner 2 breast development, reduced axillary and pubic hair, and normal e...

A 76 years old previously healthy gentleman presented with severe hypercalcaemia (5.19 mmol/l;, 2.1–2.55) and raised Parathyroid Hormone (PTH, 37 pmol/l, 1.6–7.2) after a three weeks history of confusion, diarrhoea, and weight loss. There were no other focal symptoms and family history was not significant. Other significant findings included mild recent hyponatraemia (132 mmol/l;, 136–145), acute kidney injury (urea 16.1 mmol/l, 3.2–7.4, creatinine 177 umol/l, 63–111), low vit...

Introduction: Diagnosis of Gestational Diabetes Mellitus (GDM) is with 75-g 2-hour Oral Glucose Tolerance Test (OGTT) at presentation and at 24 to 28 weeks when the first OGTT is normal. Although HbA1C is not recommended as a diagnostic test for GDM, this was used instead of OGTT during the Covid pandemic in the United Kingdom. Hemoglobin Wayne (Hb Wayne) is a rare variant of hemoglobin which may produce falsely high HbA1C level in some assays. We report a patient who was a ca...

Introduction: Thyrotoxicosis as well as its treatment with Carbimazole (CBZ) or Propylthiouracil (PTU) have been reported to result in myopathy. Onset of myalgia during the treatment of thyrotoxicosis may cause a diagnostic challenge in distinguishing the thyrotoxic from the drug-induced myopathy. We report such a case where myopathy was induced by treatment with both CBZ and PTU.Case report: We report the case of a 26-year-old Chinese lady presenting wi...

Case history: An 80-year-old woman, with a background of primary hyperparathyroidism (PHPT), presented to the emergency department with a spontaneous pathological fracture of her left femoral shaft. Blood tests revealed severe hypercalcaemia (corrected calcium 3.26 mmol/l, 2.1 – 2.55) after being lost to follow up for twenty years. She was vitamin D replete after supplementation, had normal renal functions (creatinine 76 umol/L, 50-98), and high parathyroid hormone (PTH 1...